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The threat of demonic power has returned to menace the world once again in Devil May Cry 5. The invasion begins when the seeds of a demon tree take root in Red Grave City. As this hellish incursion starts to take over the city, a young demon hunter Nero, arrives with his partner Nico in their Devil May Cry motorhome. Finding himself without the use of his right arm, Nero enlists Nico, a self-professed weapons artist, to design a variety of unique mechanical Devil Breaker arms to give him extra powers to take on evil demons such as the blood sucking flying Empusa and giant colossus enemy Goliath.